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17; 95 CI, 0. 05 to 0. 54; P 0. 001. In a subgroup analysis that included individuals without immunoglobulin heavy chain variable region IGHV mutation, the study intervention produced better progression-free survival than chemoimmunotherapy 90. 7 versus 62. 5 at three years; hazard ratio for progression or death, 0. 26; 95 CI, 0. 14 to 0. Three-year progression-free survival among subjects with IGHV mutation was 87. 7 in the ibrutinib-rituximab group and 88. 0 for conventional treatment hazard moxivul for progression or death, 0. 44, 95 CI 0. 14 to 1. The incidence of grade 3 or higher erectol plus events regardless of attribution was similar in the two groups in 282 of 352 patients 80. 1 who received ibrutinib-rituximab and in 126 of 158 79. 7 of those undergoing chemoimmunotherapy, while grade 3 or higher infectious complications were less common with ibrutinib-rituximab 37 patients 10.
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