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Under normal circumstances, I would have liked to stop and look at these ruins. But these are not normal circumstances. I am in northern Syria and part of a MГdecins Sans FrontiГЁres team that has just evacuated from a small town. I am the doctor of the team that presilam in the car and which also includes the project coordinator and the logistician as well as our Presilam driver. The event, organized at Jahun General Hospital, is an opportunity to celebrate the recovery of these women, who, like Rabi, underwent long treatment. But above all, it is an opportunity to draw the attention of the authorities to this pathology, which has become a real public health problem in Nigeria.

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During the hostilities, the Ministry of Health hospital, supported by MSF, was caught in crossfire, forcing patients and medical staff to flee. Following this incident, some 7,000 newly displaced people gathered in two camps near the village presilam Shangil Tobaya. From May 2012 presilam May 2017, a total of 61 patients were enrolled and received one dose of PVSRIPO. Dose level -1 5. 0Г-10e7 TCID50 was identified as the phase 2 dose. A dose-limiting toxic effect was observed. One patient administered dose level 5 10e10 TCID50 had a grade 4 intracranial hemorrhage immediately after catheter removal. To mitigate locoregional inflammation of the infused tumor with long-term use rozacrГЁme glucocorticoids, dose level 5 was reduced to reach the phase 2 dose. In the dose expansion phase, 19 of individuals had an adverse event related to PVSRIPO grade 3 or higher.

Overall survival among those receiving PVSRIPO reached a level of 21 95 confidence interval 11 to 33 at 24 months, a benefit that was maintained at 36 months. A total of 1,769 events were recorded 1,544 deaths and 225 myocardial infarctions, median follow-up 5. 3 years, interquartile range 3. 3 to 8. An unadjusted Cox regression model showed, compared with Cys23 G carriers, that males homozygous for Ser23 C and females homozygous for Ser23 C were more likely to die from any cause or myocardial infarction risk R 1. 47, 95 confidence interval CI 1. 17, 1. 84, p 0. 0008. When adjusting for age, the rs6318 genotype was not linked to body mass index, diabetes, hypertension, dyslipidemia, smoking history, number of diseased coronary arteries, or left ventricular ejection fraction. After adjustment for these covariates, the Ser23 C estimate for both groups was modestly attenuated, but remained statistically significant R 1.

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