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To mitigate locoregional inflammation of the infused tumor with long-term use of glucocorticoids, dose level 5 was reduced to reach the phase 2 dose. In the dose expansion phase, 19 of individuals had an adverse event related to PVSRIPO grade 3 or higher. Overall survival among those receiving PVSRIPO reached a level of 21 95 confidence bakton 11 to 33 at 24 months, a benefit that was maintained at 36 months. A total of 1,769 events were recorded 1,544 deaths and 225 myocardial infarctions, median follow-up 5. 3 years, interquartile range 3.
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