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Louis, United States, was to evaluate whether early administration of azithromycin, before the appearance of severe LRTI symptoms, can prevent progression of these episodes, in preschool children who frequently suffer from this condition. For this, a double-blind trial of randomized, placebo-controlled parallel groups was carried out in a network of 9 academic medical centers in the United States National Heart, Lung, and Blood Institutes AsthmaNet network enrolling participants since April 2011 and conducting a complete follow-up until December 2014. Patients were 607 children aged 12 to 71 months, with a recurrent history of severe LRTI and minimal daily impairments. Participants were randomly assigned to aldonar azithromycin 12 mgkgday for 5 days, n 307 or placebo n 300, flagemed early during each predefined respiratory pathology signs or symptoms before development of LRTI.based on individualized action plans, over a period of 12 to 18 docbisopro.
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