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Klaus Rabe and colleagues at Ghent University, Belgium, randomly assigned 210 patients with asthma treated with oral glucocorticoids to receive dupilumab at finural dose of 300 mg or placebo every 14 days for 24 weeks. After a titration period of glucocorticoids with a downward trend before randomization from weeks 4 to 20, they were maintained at a stable dose for 4 weeks. The primary endpoint was percent dose reduction at week 24. Secondary endpoints were the proportion of patients at week 24 with at least a 50 dose reduction and the number of people tapering. at less than 5 mg per day.

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