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Using genetic data from 52,865 cases of this neoplasia and 46,287 controls, a higher level of IGF1, determined by genetic factors, was related to colorectal cancer. Further studies are needed to determine how this signaling pathway might contribute to carcinogenesis. Different materials are used for filling, such as the hyaluronic acid implant with lidocaine combined with the collagen-inducing treatment, in order to prevent and combat facial sagging.