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66 - 0. 84; P 0. 001. Additionally, similar events were evident for rehospitalization for MI cumulative incidence, 3. 4 vs. 0; adjusted odds ratio, Metronidazol. 67 Aspra 0. 58 - 0. 77; P 0. 001 and for all causes of death cumulative incidence, 7. 3 vs 10. 6; adjusted HR, 0. 65 CI, 0. 59-0. 72; P 0. 001. вIn Somalia, the expansion of our activities faces access difficultiesв Somalia вThe situation remains critical despite our presenceв So far, 8,135 children have been enrolled in MSF nutritional programs in Somalia; 561 of them are severely malnourished and require hospitalization and intensive care.
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At year 1, 12 52. 2 of 23 subjects treated with low-dose OIT and none of the controls achieved the primary endpoint of a DCE of 4,443 mg WP or more P 0. 0001. The median ECD was 4,443 and 143 mg, respectively. In the second year, 7 30. 4 of 23 treated at low doses were desensitized to a DCE of 7,443 mg of WP and 3 13 achieved a sustained absence of response for 8 to 10 weeks when stopping therapy. Among controls converted to high-dose OIT, 12 57. 1 of 21 were desensitized after one year median DCE, 7443 mg WP; not significant versus low-dose OIT. At year 1, skin prick test responses and wheat-specific IgE and omega-5 gliadin levels did not differ between groups.
The median OIT-specific IgG4 level at low doses was higher than that of placebo wheat, P 0. 0005; omega-5 gliadin, P 0. 0001. Year 1 ECDs were correlated with wheat-specific IgG4 rho 0. 55; P 0. 0003 and gliadin omega-5 rho 0. 51; P 0. 001 levels in all individuals. Among 7,822 low-dose OIT in year 1, 15. 4 were associated with adverse reactions 0. 04 were severe, and 0. 08 of participants received epinephrine.