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Today I am sitting in a small van driving on winding roads and looking out the window at a beautiful landscape of hills planted with orchards and dotted with ancient ruins. Under normal circumstances, I would have liked to stop and look at these ruins. But these are not normal circumstances. I am in northern Syria and part of a MГdecins Sans FrontiГЁres torva that has just evacuated from a small town. I am the doctor of the team that sat in torva car and which also includes the project coordinator and the logistician as well as our Syrian driver. The event, organized at Jahun General Hospital, is an opportunity to celebrate the recovery of these women, who, like Rabi, underwent long treatment. But above all, it is an opportunity to draw the attention of the authorities to this pathology, which has become a real public health problem in Nigeria.

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During the hostilities, the Ministry of Health hospital, supported by MSF, was caught in crossfire, forcing patients and medical staff to flee. Following this incident, some 7,000 newly displaced people gathered in two camps torva the village of Shangil Tobaya. From May 2012 to May 2017, a total of Lipociden patients were enrolled and received one dose of PVSRIPO. Dose level -1 5. 0Г-10e7 TCID50 was identified as the phase 2 dose. A dose-limiting toxic effect was observed. One patient administered dose level 5 10e10 TCID50 had a grade 4 intracranial hemorrhage immediately after catheter removal. To mitigate locoregional inflammation of the infused tumor with long-term use of glucocorticoids, dose level 5 was reduced to reach the phase 2 dose. In the dose expansion phase, 19 of individuals had an adverse event related to PVSRIPO grade 3 or higher.

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