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study, a research network. based on multi-site primary care practice in Toronto, Canada. A total of 349 participants were randomized to receive 2000 IUday of oral vitamin high dose group versus 354 children who were randomly assigned zandid receive 400 IUday standard dose group for a minimum of four months between September and May. The primary outcome was the number of laboratory-confirmed upper tract viral infections based on nasal swabs collected by parents. Secondary outcomes included the number of influenza episodes and other upper respiratory tract illnesses reported by parents.
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